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BBS Funded Research Projects

BBS Funded Research Projects

Last year, the Scientific Committee of the Brittle Bone Society issued a “Call for Proposals” after securing £20,000 funding for OI research grants.

After following a detailed and thorough process and having met all the peer review requirements the committee resolved to select two outstanding projects:


Dr Meena Balasubramanian of Sheffield Children’s NHS Foundation Trust for her project Assessing the Balance of Cost and Determining the Experiences of Families in Paediatric Osteogenesis Imperfecta Healthcare (ABCD Study), said:

“I am delighted to be one of the winning recipients in the BBS first ever Grants Research Round. This generous funding will be of enormous help to the ABCD project that I am working on. Most patients with Osteogenesis imperfecta go through a prolonged patient journey before diagnosis of OI is confirmed and appropriate treatment is instituted. The ABCD study is designed to assess the healthcare needs for children with OI and how early diagnosis impacts their patient journey and healthcare costs. I look forward to reporting back on progress of my project to the BBS at their events in the coming months and years. I hope this is one of many innovative research studies funded by BBS to improve the health and wellbeing of children and families with OI.”


Dr Alex Ireland, a Lecturer in physiology at Manchester Metropolitan University for his project on physical function and soft-tissue health in individuals with OI, said:

“I am so thrilled to be one of the winning recipients in the BBS first ever Grants Research Round. Having this support will greatly benefit the study I’m working on with my colleague Prof Neil Reeves, and our clinical collaborator Prof Peter Selby from Manchester Royal Infirmary. We will research how the size and function of muscle and tendon in adults with OI are affected by the disease. This information could help us to understand health problems related to OI including tiredness, reduced mobility and dislocations. I look forward to reporting back on progress of my project to the BBS at their events in the coming months and years.”

Both participants were awarded the grants in January 2018.

Vibrating Plates

Study now closed

In 2010, the Brittle Bone Society provided Dr Hogler with funding to carry out the whole-body vibration research.

Whole body vibration was a study to look at treatment options to improve mobility, muscle strength and bone strength.  Children between 5 and 18 years of age with Osteogenesis Imperfecta (type 1 or 4) were invited to take part in a randomised controlled trial at Birmingham Children’s Hospital.

The study was to test whether daily vibration training (2x10min) for 5 months improved mobility, balance, muscle strength, and bone strength.

Children were trained to use the vibration device and subsequently the device was delivered to the child’s home, where training was supervised and monitored by a Physiotherapist.

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